红葡萄酒为什么可以抗癌，本文主要内容关键词为：红葡萄酒论文，此文献不代表本站观点，内容供学术参考，文章仅供参考阅读下载。
研究人员认为他们已经破解了一个奥秘——葡萄和红酒中含有的一种抗氧化剂是如何抗癌的。
[2]星期五发表的一项研究结论说，白藜芦醇这种化合物的作用如同一种抗生素，能保护葡萄免受真菌的侵扰，可以使抗癌疗法（比如化疗）中能够保护癌细胞的蛋白质失去活性。
[3]查佩尔希尔市北卡罗来纳大学医学院的一位营养生物学家明妮·霍姆斯－麦克纳里说，此项研究有朝一日会让这种化合物本身用于癌症的预防与治疗。
[4]该研究报告的主要作者霍姆斯－麦克纳里说：“其价值在于它的确开辟了一片潜在的治疗癌症的新天地。”有可能包括口服一种药片，如同补充维生素那样。
[5]法国人的饮食中胆固醇的含量较高，但其心脏病的发病率却较低，这种“法兰西怪事”被发现之后的过去十年间，小酌一杯红葡萄酒的好处一直被人们大肆宣扬。研究结果已经表明，其中的关键可能就是吃饭时摆在餐桌上的那几杯红葡萄酒。
[6]几年前，研究者们发现白藜芦醇可以防止细胞癌变并阻止恶性肿瘤扩散。白藜芦醇还可抑制细胞发炎，这种细胞发炎与关节炎及其他疾病有着关联。
[7]很多食物中都含有白藜芦醇，其中有桑葚和花生。所有的葡萄酒中都含有一些白藜芦醇，不过红葡萄酒中的含量似乎是最丰富的。
[8]霍姆斯－麦克纳里及其合作者——医学院莱恩伯格综合癌症中心的小艾伯特·鲍德温——想要搞清楚白藜芦醇是怎样杀死癌细胞的。他们的调查结果发表在七月份的《癌症研究》杂志上。
[9]研究者们使用了鲍德温等人先前的研究结果，确认一种叫做NF－卡巴粒B的蛋白质能够使得肿瘤细胞即使在化疗中也可以存活下来。正如去年的一项研究显示，当老鼠体内的NF－卡巴粒B被抑制时，癌细胞便可在化疗过程中被彻底杀死。
[10]霍姆斯－麦克纳里和鲍德温测试了培植的人和动物的肿瘤细胞是如何对白藜芦醇起反应的，结果发现它确实可以使NF－卡巴粒B这种癌症基因丧失活性。霍姆斯－麦克纳里说，未经处理的肿瘤继续存活着。
[11]芝加哥伊利诺伊大学研究人员约翰·皮苏托说，发现白藜芦醇的机理作用对人类将这种化合物开发成为抗癌药物起着至关重要的作用。这种研究人员曾于1997年首次报告了白藜芦醇与红葡萄酒的联系及其抗癌作用。
[12]皮苏托谈及此项研究时说：“这是一项很好的研究成果，看起来有多种的机理作用。最终，在它们背后可能隐含有一条共同的主线。我们似乎正在破解一部分难题，而这只是其中之一。”
[13]由国家健康研究所及美国心脏协会北卡罗来纳州分会共同资助的这项研究还发现，麝香葡萄酒中白藜芦醇的含量比普通红葡萄酒高7倍之多。
Researchers believe they have unlocked the mystery of how an antioxidant（注：
抗氧化剂oxidant氧化剂） found in grapes and red wine fights carncer.
[2] A study published Friday concludes that the compound resveratrol,which acts like an antibiotic（注：
抗生素）to protect grapes from fungus（注：
真菌（含霉菌、酵母菌）；易生长物）,may turnoff a protein（注：蛋白质；朊）that guards cancer cells from cancer-fighting therapies（注：
治疗；疗法）such as chemotherapy（注：
化学疗法）.
[3] The research may one day allow the compound itself to be used in cancer prevention and treatment,said Minnie Holmes-McNary,a nutritional biologist at the University of North Carolina's medical school in Chapel Hill.
[4] "The benefit is that it certainly provides anopen door for potential therapies," said Holmes-McNary,the study's lead author.That may include taking a pill similar to a vitamin supplement.
[5] The benefits of drinking a glass of red winehave been touted over the past decade after the discovery of the "French paradox（注：
反论；谬论；怪事）"—that the French had low rates of heart disease despite high-cholesterol（注：
高胆固醇）diets.Studies have shown the key may be the glass or two of red table wine at dinner.
[6] A few years ago,researchers found that resveratrol kept cells from turning cancerous and stopped the spread of malignancies（注：
恶性肿瘤）.Resveratrol also blocked cell inflammation,which is linked to arthritis（注：
关节炎）and other diseases.
[7] Resveratrol can be found in dozens of foods,including mulberries and peanuts.All wines have some resveratrol,but red wine seems to be its richest source.
[8] Holmes-McNary and co-author Albert Baldwin Jr.at themedicalschool's Lineberger Comprehensive Cancer Center wanted to know how resveratrol kills cancercells.Their findings were published in the July issue of the journal Cancer Research.
[9] The researchers used previous research by Baldwin and others that determined the protein called NF-kappa（注：
〔遗传学〕卡巴粒）B enabled tumor cells to surviveeven chemotherapy.When NF-kappa B is blocked in mice-as observed last year in a study-the cancer cells were eradicated（注：
根除；消灭）by the chemotherapy.
[10] Holmes-McNary and Baldwin tested how cultured human and animal tumor cells reacted to the resveratrol,learning that it effectively turned off the NF-kappa B cancer gene.Untreated tumors continued to thrive,Holmes-McNary said.
[11]Discovering the mechanisms of resveratrol is important to developing the compound as a cancer-preventive agent for humans,said John Pezzuto,a University of Illinois at Chicago researcher who first reported resveratrol's link to red wine and fighting cancer in 1997.
[12] "It's a good contribution," Pezzuto said of the study."It seems like there are multiple mechanisms.In the end,there may be a common thread to all of them.It's like we're laying down pieces of the puzzle.This is one of those pieces."
[13] The study,funded by the National Institutes of Health and the North Carolina chapter of the American Heart Association,also found muscadine（注：
麝香葡萄；圆叶葡萄）wines contain up to seven times more resveratrol than regular wines.