赵燕妮1 武 革1（通讯作者） 陈玉华2 伍晓聪1
1.广东医科大学附属医院内分泌科 广东湛江 524001；2.深圳市龙岗区人民医院内分泌科 广东深圳 518116
【摘 要】目的 观察骨质疏松患者高血压与骨形成指标骨钙素（OC）的相关性。方法 对452例大于50岁骨质疏松患者进行横断面研究，观察高血压与OC的相关性。用电化学发光免疫分析测定骨形成标志物。结果 根据血压水平将所有患者分为高血压组及无高血压组，按性别分层，校正可能的混杂因素后，女性高血压组OC水平低于无高血压组，而男性高血压组OC水平与无高血压组无统计学差异。结论 高血压病与女性中老年骨质疏松患者低骨钙素水平相关，可能是该人群骨量低下及骨质疏松发生的风险因素之一，但结论仍有待进一步研究证实。
【关键词】骨质疏松；高血压；骨钙素；相关性
Correlation analysis of hypertension and bone formation markers in osteoporosis patients
ZHAOYan-ni1，WUGe1（corresponding author），CHENYu-hua2，WUXiao-cong1
（1. Department of Endocrinology，Affiliated Hospital of Guangdong Medical University，Zhanjiang，Guangdong，524001；2. Department of Endocrinology，
Shenzhen Longgang people's Hospital，Shenzhen，Guangdong，518116）
Abstract：Objective To investigate the Correlation of hypertension with bone formation markers osteocalcin（OC）in Chinese Osteoporosis patients. Methods A cross-sectional study with 452（＞50 years）Chinese osteoporosis patients was carried out. The Correlation of hypertension with the bone formation markers of OC was observed and the OC concentration were measured by ECL immunoassay. Results The patients were divided into hypertension group and no hypertension group according to the blood pressure level. After adjusting for multiple confounders，the OC level in hypertension group were lower than that in no hypertension group of women patients. However，the relationship between hypertension and bone formation markers in men patients was found no significant difference. Conclusion Hypertention was associated with the lower OC level in Chinese osteoporosis of female patients，and it might be the risk factor for low bone mineral density and osteoporosis，however，the relative conclusion need to be confirmed by further studies.
Key words：Osteoporosis；hypertention；osteocalcin；relevance
论文作者:赵燕妮1,武,革1（通讯作者）,陈玉华2,伍晓聪1
论文发表刊物:《中国医学人文》(学术版)2018年1月第1期
论文发表时间:2018/5/19
标签：高血压论文; 骨质疏松论文; 相关性论文; 患者论文; 水平论文; 广东论文; 结论论文; 《中国医学人文》(学术版)2018年1月第1期论文;