哈尔滨市呼兰区第一人民医院 150500
摘要：目的：分析老年高血压合并高脂血症患者采用阿托伐他汀钙治疗的降脂作用及安全性。方法：随机的选择2017年2月到2018年2月来我院就诊的老年高血压合并高脂血症患者60例，按照随机分配的原则将这60名患者分成两组，每组30人。分别将这两个组命名为实验组和对照组。对照组采用常规的药物对患者进行治疗，实验组在对照组的基础上配合阿托伐他汀钙进行治疗。经过一段时间的治疗之后，对比两组患者的血压水平、血脂指标、不良反应发生率以及用药安全性等指标。最终判断阿托伐他汀钙对老年高血压合并高脂血症患者降脂作用是否明显，并且判断用药是否安全。结果：治疗后,实验组和对照组的收缩压、舒张压均低于实验前，而且实验组收缩压、舒张压均低于对照组，实验组的HDL-C、LDL-C、TC、TG也均优于对照组,差异具有统计学意义(P<0.05)。除此之外，实验组患者的不良反应发生概率明显要低于对照组，用药的安全性也很好。结论：阿托伐他汀钙对帮助改善高血压合并高脂血症患者的血压、血脂情况有明显效果,且用药不良反应发生率低,值得在临床实践中推广应用。
关键词：阿托伐他汀钙；老年高血压合并高脂血症；降脂
Effect of atorvastatin calcium on lipid-lowering and safety of elderly patients with hypertension complicated with hyperlipidemia
OBJECTIVE: To analyze the lipid-lowering effect and safety of atorvastatin calcium in elderly patients with hypertension and hyperlipidemia. METHODS: Sixty patients with hypertension and hyperlipidemia who were admitted to our hospital from February 2017, to February 2018 were randomly selected. The 60 patients were divided into two groups according to the principle of randomization, 30 in each group. The two groups were named as the experimental group and the control group, respectively. The control group was treated with conventional drugs, and the experimental group was treated with atorvastatin calcium on the basis of the control group. After a period of treatment, the blood pressure levels, blood lipids, incidence of adverse reactions, and medication safety were compared between the two groups. Finally, it is judged whether atorvastatin calcium is effective in reducing blood lipids in elderly patients with hypertension and hyperlipidemia, and whether the medication is safe. RESULTS: After treatment, the systolic and diastolic blood pressures of the experimental group and the control group were lower than those before the experiment, and the systolic and diastolic blood pressures of the experimental group were lower than those of the control group. HDL-C, LDL-C, TC, TG of the experimental group. They were also superior to the control group, and the difference was statistically significant (P<0.05). In addition, the incidence of adverse reactions in the experimental group was significantly lower than that in the control group, and the safety of the medication was also good. Conclusion: Atorvastatin calcium has obvious effects on improving blood pressure and blood lipids in patients with hypertension and hyperlipidemia, and the incidence of adverse drug reactions is low, which is worthy of popularization and application in clinical practice.
Key words: atorvastatin calcium; senile hypertension with hyperlipidemia; lipid-lowering
引言：高血压病病人往往合并脂质代谢紊乱,而高脂血症也会增加心血管事件风险,严重影响高血压病病人预后[1]。而且高血压的病程长，严重威胁到患者的身心健康［2］。临床治疗中,常见的方法以药物控制为主,如用药选择阿托伐他汀钙,其对帮助控制患者血压、血脂有积极作用。本文对阿托伐他汀钙对老年高血压合并高脂血症患者降脂作用及安全性进行探讨，从而判断其是否值得在临床上被推广。
资料与方法
1.1一般资料
随机的选择2017年2月到2018年2月来我院就诊的老年高血压合并高脂血症患者60例，按照随机分配的原则将这60名患者分成两组，每组30人。分别将这两个组命名为实验组和对照组。实验组患者当中有男性患者16例,女性患者14例,年龄分布在62-85岁之间,平均年龄为(71.87±5.34)岁｡对照组患者当中有男性患者15例,女性患者15例｡年龄分布在62-83岁之间,平均年龄在(71.24±3.34)岁｡两组患者一般资料比较,差异无统计学意义(P>0.05),具有可比性。
1.2方法
对照组采用常规的药物对患者进行治疗，实验组在对照组的基础上配合阿托伐他汀钙进行治疗。常规药物中包含钙通道阻滞剂、血管紧张素转换酶抑制剂、β受体阻滞剂等。实验组患者均服用阿托伐他汀钙20mg，每晚1次。经过三个月的治疗之后对患者的血压水平、血脂指标、不良反应发生率以及用药安全性等指标进行检查，从而明确阿托伐他汀钙治疗高脂血症的效果。
2.结果
3.讨论
高血压与高脂血症关系密切,往往相互影响、相互促进[3]。二者之间相互作用，逐渐导致动脉硬化，引发脑血栓、心脏病等疾病，威胁到患者的生命健康。临床治疗中,通常选择药物控制治疗为主,常规用药选择血管紧张素转换酶抑制剂、β受体阻滞剂等,在帮助缓解患者血压、血脂症状方面有积极作用,但治疗效果并不明显。通过上述实验结果来看，治疗后,实验组和对照组的收缩压、舒张压均低于实验前，而且实验组收缩压、舒张压均低于对照组，实验组的HDL-C、LDL-C、TC、TG也均优于对照组,所以阿托伐他汀钙对帮助改善高血压合并高脂血症患者的血压、血脂情况有明显效果,且用药不良反应发生率低,值得在临床实践中推广应用。
参考文献：
[1]张世阳,王卫东,谈敏.阿托伐他汀积极降脂改善临床预后[J].中国临床保健杂志,2006,9(1):88-90.
[2]吴荻.阿托伐他汀钙治疗高脂血症的临床分析[J].中国医药指南,2011,9(23):80-81.
[3]李军,刘培良.阿托伐他汀对老年高脂血症的疗效观察[J].实用心脑肺血管病杂志,2011,19(5):800-801.
论文作者:叶大勇
论文发表刊物:《中国结合医学》2019年第01期
论文发表时间:2019/4/8
标签：实验组论文; 患者论文; 高血压论文; 对照组论文; 高脂血症论文; 收缩压论文; 老年论文; 《中国结合医学》2019年第01期论文;