黑龙江省伊春市中心医院 黑龙江 伊春市 153000
摘要：目的：探究乳酸菌联合氯喹那多-普罗雌烯阴道给药治疗高龄萎缩性阴道炎患者的疗效。方法：选取我院2016年8月-2017年8月期间收治的80例萎缩性阴道炎患者做研究对象，随机均分为治疗组和对照组两组，每组40例。其中治疗组使用乳杆菌活菌制剂联合氯喹那多-普罗雌烯阴道片进行治疗，对照组单用氯喹那多-普罗雌烯阴道片进行治疗，疗程为10d，随访观察1周、1个月临床疗效。 结果：两组治疗1周复诊，治疗组治愈31例(77.5%)，有效7例(17.5%)，无效2例(5.0%)，有效率95.0%。对照组治愈26例(65.0%)，有效3例(7.5%)，无效11(27.5%)，有效率72.5%。两组治疗效果比较，治疗组优于对照组，差异具有统计学意义。两组治疗后1个月复诊，治疗组治愈35例，复发5例，复发率12.5%；对照组治愈28例，复发12例，复发率30%。两组复发率比较，差异有统计学意义。结论：乳酸菌联合氯喹那多-普罗雌烯阴道给药治疗萎缩性阴道炎高龄患者，可有效缓解其临床症状和体征，降低复发风险，且安全性较高。
关键词：乳酸菌，氯喹那多-普罗雌烯；萎缩性阴道炎；疗效
Lactic acid bacteria combined with chlorquinadol-promethine vaginal treatment for elderly patients with atrophic vaginitis
Abstract : Objective: To investigate the efficacy of vaginal administration of lactic acid bacteria combined with chloroquinado-pro-estrom in the treatment of atrophic vaginitis in the elderly. Methods: A total of 80 cases of atrophic vaginitis treated in our hospital from August 2016 to August 2017 were selected and randomly divided into treatment group and control group, with 40 cases in each group. The treatment group used Lactobacillus viable preparations combined with chlorquinadol-promethine vaginal tablets for treatment. The control group was treated with chlorquinadol-promethine vaginal tablets alone. The treatment course was 10 days. Follow-up observation for 1 week and 1 month Clinical efficacy. Results: After two weeks of treatment in the two groups, 31 cases (77.5%) were cured in the treatment group, 7 cases (17.5%) were effective, 2 cases (5.0%) were ineffective, and the effective rate was 95.0%. In the control group, 26 cases (65.0%) were cured, 3 cases (7.5%) were effective, 11 (27.5%) were ineffective, and the effective rate was 72.5%. The therapeutic effects of the two groups were better in the treatment group than in the control group, and the difference was statistically significant. After two months of treatment, the patients were referred to the hospital one month later. In the treatment group, 34 cases were cured, 5 cases relapsed, and the recurrence rate was 12.5%. In the control group, 28 cases were cured and 12 cases relapsed. The recurrence rate was 30%. The recurrence rate between the two groups was statistically significant. Conclusion: Lactobacillus combined with chlorquinadol-promethine vaginal administration in the treatment of elderly patients with atrophic vaginitis, can effectively relieve the clinical symptoms and signs, reduce the risk of recurrence, and high safety.
Key words: lactic acid bacteria, chloroquinado-proestrene; atrophic vaginitis; curative effect
1资料和方法
1.1基本资料
萎缩性阴道炎（亦称老年性阴道炎）常见于自然绝经及卵巢去势后妇女，是临床上常见的一种妇科疾病。国内报道老年性阴道炎的发病率为30.0%-58.6%。萎缩性阴道炎多采用局部或全身应用抗菌药物治疗，但容易破坏阴道正常菌群，造成二重感染，且远期复发率较高。如何有效提高萎缩性阴道炎患者的临床疗效，改善阴道微环境并降低复发风险已成为临床关注的热点。本研究观察了乳酸菌联合氯喹那多-普罗雌烯阴道给药治疗萎缩性阴道炎高龄患者的疗效及复发率，现报道如下。
1.2基本方法
选取2016年8月-2017年8月在本院妇科门诊就诊的绝经2年后妇女，选择满足诊断标准的萎缩性阴道炎患者80例，1周内未用过抗生素及无阴道用药。年龄45-77岁，平均57.5岁，无用药禁忌证。纳入标准：符合《妇产科学》中萎缩性阴道炎的诊断标准者；年龄≥70岁；阴道清洁度Ⅲ-Ⅳ度；阴道分泌物未见滴虫、假丝酵母菌和淋病奈瑟菌。排除标准：合并宫颈恶性病变者；合并糖尿病者；长期使用糖皮质激素者；3个月内全身或阴道局部使用雌激素者；对本研究药物过敏者；严重肝肾功能障碍者；精神系统疾病者；临床资料不全者。
2结果
表1：两组治疗效果比较n(%)
3讨论
上述结果表明，乳杆菌活菌制剂联合氯喹那多-普罗雌烯阴道片治疗萎缩性阴道炎近期及远期疗效确切，建议推广应用。
参考文献
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[2]李莉.乳杆菌活菌制剂联合氯喹那多-普罗雌烯阴道片治疗萎缩性阴道炎疗效观察[J].药物与临床,2011,18（7）:77-78.
[3]翁时清.乳杆菌活菌制剂联合氯喹那多-普罗雌烯阴道片治疗萎缩性阴道炎的近期和远期疗效[J].海峡药学,2012,24（9）:130,131.
论文作者:刘铁艳
论文发表刊物:《中国研究型医院》2018年5卷2期
论文发表时间:2018/7/3
标签：阴道炎论文; 氯喹论文; 阴道论文; 普罗论文; 萎缩性论文; 那多论文; 疗效论文; 《中国研究型医院》2018年5卷2期论文;